What Is VDR?

VDR is a gene which encodes for a protein which functions as a receptor for vitamin D that regulates bone development and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a decreased bone mineral density among white prepubescent girls.

The hnRNP C1/C2 component of the nuclear https://www.gescheftmarketing.de/2021/09/01/what-is-the-best-school-coding-platform/ vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by two components, and is affected by chromosomal locations and by binding preferences for certain hormones. Microarray studies in human cells have revealed that more than 100 genes have VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for information and documents relevant to legal transactions, business or proceedings with restrictions on viewing and downloading. It uses a central computer and an extranet which is a restricted-access Internet connection, allowing users to access the internet at specific times.

Investment bankers and companies involved in mergers and acquisitions are the most frequent users of a VDR. They need to be able to share information in a transparent way with potential investors or buyers. Due diligence may also require a huge amount of information. Life science companies also use VDRs to keep everything from clinical trial results to HIPAA documentation.